The management of children with epilepsy at Johns Hopkins has a long and proud history. Dr. Edwards Park, Director of the Harriet Lane Home of Johns Hopkins was the first to establish specialty clinics in pediatrics. Pediatric epilepsy was initiated during the 1940's first under Lawson Wilkens who ran it part time (later to return full time as Director of the Pediatric Endocrine Clinic), then Drs. Bridge and Laslo Kajdi. During the 1950's and 60's it was one of the premier epilepsy programs under the direction of Dr. Samuel Livingston and his associate Dr Lydia Pauli. They set the standard for caring, comprehensive care of children with epilepsy and wrote many outstanding books and articles in the field.

In 1969 Dr John Freeman returned from Stanford to create and direct the Pediatric Neurology service at Hopkins, and with Dr. Livingston's retirement in 1973 assumed directorship of the pediatric epilepsy clinic, renamed The Pediatric Epilepsy Center.

Over the years, this outstanding center has had major impact on the treatment of febrile seizures in children; on major surgeries, such as hemispherectomies for devastating epilepsies; and with the resurrection of the ketogenic diet as therapy for difficult-to-control seizures.

The Center has been leading the clinical efforts for the comprehensive care of children with epilepsy and their families. Its comprehensive, team approach developed together with Dr. Eileen P.G. Vining, its long-time associate director, and now director, Diana Pillas, coordinator/counselor; Paula Pyzik, data coordinator, Jane McGrogan, dietitian, and the recent addition of Drs Eric Kossoff and James Rubenstein continue to keep this one of the outstanding Epilepsy Centers for children in the world.