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 Multiple sclerosis is an inflammatory disorder of the central nervous system in which the white matter is the target of immune and cellular reactions that lead to the destruction of myelin, axons and oligodendrocytes. The last decade of research on multiple sclerosis (MS) brought new information about MS pathogenesis and important improvements in the imaging of MS lesions. Recent developments in immunopathology and morphological analysis of brain tissue from patients with MS have exposed significant disease heterogeneity and refined previous pathological observations that contribute to a better understanding of the clinical presentation and progression of disease. These advances are particularly important in the delineation of profiles of pathological changes that occur during the different stages and variants of MS. Such knowledge is critical for the development of new therapeutic strategies to target disease progression. Our Research on Multiple Sclerosis Immunopathology Our laboratory supports the Multiple Sclerosis Center in projects related with neuropathological analysis of brain tissues to determine the role of immune mechanisms mediated by T lymphocytes, microglia and astroglia. An effort to collect brain tissues from patients with MS through a program of brain and spinal cord tissue banking is part of our effort to improve research on areas of pathogenesis. Multiple Sclerosis links:
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