Molecular Neuroscience
Two laboratories study the molecular mechanisms of neuronal death with a special emphasis on Parkinson's disease, AIDS dementia, Alzheimer's disease and stroke. Our laboratories are currently focusing on the role of nitric oxide and the intracellular death pathways that it activates in these neurologic disorders. Our laboratories utilize state-of-the-art molecular biochemical and cell biological approaches to study mechanisms of neuronal cell death. Fellowship opportunities are available for two to three years.

For information contact:
Ted Dawson, MD, PhD
or Valina Dawson, PhD
The Institute for Cell Engineering
Broadway Research
Bldg
Suite 731
733 N. Broadway
Baltimore, MD
21205
tele: 410-614-3359
Fax: 410-614-9568
e-mail: tdawson@jhmi.edu
e-mail: vdawson@jhmi.edu
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Molecular
Mechanisms of Neurodegeneration
This laboratory investigates various mechanisms associated with chronic neurodegenerative diseases with particular emphasis on amyotrophic lateral sclerosis. The laboratory is currently focused on the biology of molecular types of glutamate transporters including regulatory processes, synaptic targeting, mutations associated with disease; transgenic animal models of ALS including over-expressing and knock-in SOD1 mutants; biology of selective motor neuron degeneration. The laboratory offers opportunities in an environment that includes state-of-the art molecular biology, immunohistochemical/ immunoelectron microscopic analysis, in vitro and in vivo models of chronic neurodegeneration. Opportunities exist to engage in new research based on novel therapeutics including neural stems cells and gene therapy focusing on glutamate transporters Post-doctoral opportunities are available for two to three years.
For information contact:
Jeffrey D. Rothstein,
MD, PhD
Meyer 6-109
The Johns
Hopkins Hospital
600 N. Wolfe Street
Baltimore, MD 21287
tele: 410-614-5972
Fax: 410-955-0672
e-mail: jrothste@jhmi.edu
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