19-Nov-2004
Nicholas Gaiano, PhD
Dr. Gaiano joined the Department of Neurology as an Assistant Professor in 2002, and is a member of the Graduate Program in Neuroscience. He is also a member of the recently established Institute for Cell Engineering (ICE) in the Neurobiology Program.

Current studies in the lab examine the development of the mammalian forebrain using the mouse as the model system. In particular, the lab focuses on understanding the molecular mechanisms that regulate neural stem cell maintenance, proliferation, and the specification of post-mitotic cell types. Recent work has found that the Notch and FGF signaling pathways are intimately involved in these processes, and ongoing studies are continuing to pursue these pathways among others. Both in vivo and in vitro approaches are being undertaken to pursue this work. An ultrasound image-guided injection system is used to introduce viral vectors into the developing brain in utero prior to the onset of neurogenesis. The fate of genetically modified cells is then examined in vivo, or these cells are isolated using fluorescence-activated cell sorting (FACS) for in vitro analysis. Close coordination of both loss-of-function and gain-of-function studies, with in vivo and in vitro assays, should provide greater insight into the molecular and cellular regulation of cell-fate specification during brain development.

CURRENT ADDRESS
The Johns Hopkins Hospital
Department of Neurology
Institute for Cell Engineering
733 N. Broadway, Room 715
Baltimore, MD 21205


Phone: 443-287-4866
Fax: 443-287-4868
e-mail: ngaiano1@jhmi.edu
    EDUCATION & TRAINING
  • 1991, B.S., Biochemistry, Cornell University, Ithaca, NY
  • 1997, Ph.D., Biology, Massachusetts Institute of Technology, Cambridge, MA
  • 1997-2002, Post-doctoral Fellowship, New York University
    Skirball Institute of Biomolecular Medicine, New York, NY
    CURRENT APPOINTMENTS
  • Assistant Professor of Neurology & Neuroscience
    The Johns Hopkins University School of Medicine, Baltimore, MD
  • Assistant Investigator, The Institute for Cell Engineering (ICE)
    The Johns Hopkins University School of Medicine, Baltimore, MD
    HONORS & AWARDS
  • 1997-2000 Postdoctoral Fellowship - American Cancer Society
  • 2001-2005 Career Award in Biomedical Sciences - Burroughs Wellcome Fund
  • 2003-2005 Kimmel Cancer Scholar - Sidney Kimmel Cancer Foundation
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