October 1999  
 

Dr. Piotr Franaszczuk has been a member of the Department of Neurology since 1999. and currently is an Assistant Professor of Neurology. His research in the Epilepsy Research Laboratory is concentrated on  localization and detection of seizure onset in patients with epilepsy, analysis of dynamics of seizure spread in time and space, and modeling of seizure generation and propagation.  He is developing and implementing computational methods of signal analysis and neural modeling.  Methods of EEG signal analysis include multichannel autoregressive modeling, Direct Transfer Function (DTF) method and time-frequency analysis using the Matching Pursuit algorithm.

A large (~65,000) realistic neuron network model developed in Epilepsy Research Laboratory is used to investigate patterns of propagation of epileptiform activity and its dependence on connectivity and physiological properties of neurons and synapses.

  
 
  The Johns Hopkins Hospital
Department of Neurology
Meyer 1-163
600 N. Wolfe Street
Baltimore, MD 21287
Phone: 410-614-8770
Fax: 410-955-0751
E-Mail: pfranasz@erl.neuro.jhmi.edu		  
 
  • 1978 M.Sc., Physics, Warsaw University, Warsaw, Poland. Thesis: "Analysis of visual evoked potentials by means of maximum entropy method"
  • 1988 Ph.D., Physics, Warsaw University, Warsaw, Poland.  Thesis: "Modeling of electrical activity of the selected brain structures"
  • 1989-91 Bennett Fellowship in Neurophysiology, Department of Neurology, University of Maryland School of Medicine, Baltimore, MD.
  
 
  • Assistant Professor of Neurology, The Johns Hopkins University School of Medicine
 
 
  • 1998 Epilepsy Foundation, Junior Investigator Award
  • 1988 Award of Ministry of Education of Poland
  • 1984,1988  Awards of the President of Warsaw University
  • 1984 1st prize in national competition for computer tomography reconstruction algorithm
 
 
  • Principal Investigator:
    1. NIH, NINDS, RO1 NS38958-01 "A Neural Network Model of Epileptiform Activity"
    2. Epilepsy Foundation, Junior Investigator Grant "A Neural Network Model of Propagation of Epileptiform Activity"
  • Co-Principal Investigator:
    1. NIH, NINDS, RO1 NS33732-04 "Multichannel Parametric Analysis of Seizure Propagation"
  
 
  • P.J. Franaszczuk, G.K. Bergey. An autoregressive method for the mesurement of synchronization of interictal and ictal EEG signals. Biol. Cybern., 81:3-9, 1999.
  • P. Kudela, P.J. Franaszczuk, G.K. Bergey. Model of the propagation of synchronous firing in a reduced neuron network. Neurocomputing, 26-27:411-418, 1999.
  • P. J. Franaszczuk, G.K. Bergey, P.J. Durka, H.M. Eisenberg. Time-frequency analysis using matching pursuit algorithm applied to seizures originating from the mesial temporal lobe. Electroenceph. clin. Neurophysiol. 106:513-521, 1998.
  • P.J. Franaszczuk, G.K. Bergey. Application of the directed transfer function method to mesial and lateral onset temporal lobe seizures.  Brain Topography, 11:13-21, 1998.
  • E.F. Kelly, J. E. Lenz, P.J. Franaszczuk, Y.K. Truong. A General Statistical Framework for Frequency-Domain 

    • Analysis of EEG Topographic Structure. Comput  Biomed. Res. 30:129-164, 1997.
  • P. Kudela, P.J. Franaszczuk, G.K. Bergey.  A simple computer model of excitable synaptically connected neurons.  Biol. Cybern. 77:71-77, 1997.
  • P. J. Franaszczuk, G.K. Bergey, P.Kudela. Detection of spontaneous postsynaptic potentials. Comput Biomed. Res. 28:354-370, 1995.
  • P. J. Franaszczuk, G.K. Bergey, M.J.Kaminski. Analysis of mesial temporal seizure onset and propagation using the directed transfer function method. Electroenceph. clin. Neurophysiol., 91:413-427, 1994.
  • K.J. Blinowska, P.J. Franaszczuk, M. Kaminski. Parametric methods of EEG Analysis. In: Mathematical approaches to brain functioning diagnostics. Proceedings in Nonlinear Science. Eds. I.Dvorak, A.V.Holden. Manchester University Press, Manchester, New York, pp:139-157, 1991.
  • P.J. Franaszczuk, P. Mitraszewski, K.J. Blinowska. FAD-parametric description of EEG time series. Acta Physiol.Polon. 40:418-422, 1989. 
  • K.J. Blinowska, P.J. Franaszczuk. A Model of the Generation of Electrocortical Rhythms. In: Brain Dynamics:Progress and Perspectives. Springer Series in Brain Dynamics 2. Eds. E.Basar, T.H. Bullock. Springer-Verlag Berlin Heidelberg, pp:192-201, 1989. 
  • K. Leszczynski, P.J. Franaszczuk, P. Penczek. An alternative reconstruction algorithm for NMR imaging. Medical & Biological Engineering & Computing, 26:186-192, 1988. 
  • P.J. Franaszczuk, K.J. Blinowska, M. Kowalczyk. The application of parametric multichannel spectral estimates in the study of electrical brain activity. Biol.Cybern., 51:239-247, 1985. 
  • P.J. Franaszczuk, K.J. Blinowska. Linear model of brain electrical activity - EEG as a superposition of damped oscillatory modes. Biol.Cybern., 53:19-25, 1985. 
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