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Dr. Harvey
S. Singer is Professor of Neurology and Pediatrics at the Johns
Hopkins University and Director of Pediatric Neurology at the Johns Hopkins
Hospital. He has dedicated his career to treating patients with Tourette
Syndrome and leads a team of researchers in a comprehensive effort to find
a cure for Tourette Syndrome. Dr. Singer is a world renowned expert in Tourette
Syndrome and other pediatric movement disorders with hundreds of publications
and book chapters to his credit.If you are interested in participating in any of the studies listed below, or would like further information, please e-mail Dr. Singer, or contact him by telephone at 410-614-4869. If you would like to help support our research through a tax-deductible contribution, you may do so by sending your check or money order to: The Friends of Tourette Syndrome Research The Johns Hopkins Hospital Jefferson Building, Room 123 600 N. Wolfe Street Baltimore, MD 21287 ATTN: Harvey Singer, M.D. Studies currently underway include:  "Dopamine Receptor Polymorphism in Tourette Syndrome: A predictor to response to tic suppressing medications?" Several established genetic variations (polymorphisms), including those from of metabolizing enzymes, dopamine and serotonin transporters, dopamine receptors and serotonin receptors are being investigated in children and adults with TS using DNA obtained from buccal swabs. Major objectives include: (1) establishing the prevalence of polymorphisms in TS patients; and (2) determining whether presence of specific patterns of neurotransmitter polymorphisms can predict the tic-suppressing pharmacologic effect of typical and atypical neuroleptics. Study participation does not require the patient to take new or additional medications. Study population: Adults and children with chronic tics or TS. 
"Genetic Linkage Study of Gilles de la Tourette Syndrome" The purpose of this study is to determine whether TS is a genetically linked disorder. Study population: Siblings, both of whom have TS, or one parent and child, both with TS.  Study 1: "Factors Affecting Dopaminiergic Neurotransmission in Tourette Syndrome" Study 2: "Serotonin Pre- and Post-synaptic Neurotransmission in Tourette Syndrome" These studies investigate the uptake of seratonin or dopamine to determine if there is a difference in chemical activity in Tourette patients and non-Tourette patients. Study population: Adults. Study participants will be compensated. |
